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As with any supplement, it’s important to know what it does, and whether the hydroxycitric acid side effects are mild or serious in nature.
Hydroxycitric acid is a chemical compound found in the rind or skin of the Garcinia cambogia fruit.
Also known as HCA, Garcinia cambogia and hydroxycitric acid are often used interchangeably to define the same supplement available in natural and health food stores, drug stores, and supplement markets around the world. Click here to buy Garcinia Cambogia online.
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Garcinia Cambogia contains 60% HCA (Hydroxycitric Acid) to promote weight loss. This supplement may help control appetite and block the digestion of carbs... READ MORE
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Table of Contents
In a number of laboratory studies on animals (mainly mice and rats), hydroxycitric acid shows potential in its ability to affect lipid (fat) metabolism, which can lead to weight loss.
How does it work? A number of components of hydroxycitric acid are believed to have the ability to inhibit the enzyme adenosine triphosphate citrate (pro-3S) lyase.
Chemical interaction between many of these chemical constituents is required by the body for the creation of fat cells and storage.
Inhibiting these reactions may limit the ability and availability of certain components involved in the synthesis of fatty acids and lipogenesis (production/creation of fat) following a high carb diet.
Weight gain is caused when a person consumes more calories than they burn off.
When your calorie intake exceeds the energy expenditure of your body needs for fuel, excess glucose (the body’s main form of energy) is turned into glycogen, which is stored in the muscles as well as the liver for use at a later time.
It is not known whether Hydroxycitric acid liver damage is a result of taking the supplement.
When the body reaches its capacity for glycogen storage, weight gain can occur.
Excess amounts of glucose from consuming too many calories is converted into acetyl coenzyme A through a variety of metabolic processes that use ATP citrate lyase.
Another component involved in the production of fat molecules, which are then stored in fat cells. In effect, HCA inhibits this process.
In addition, HCA is believed to suppress the appetite, although how this works, or the mechanism of action involved in suppressing the appetite has not been studied in humans.
However, a number of animal studies have shown positive results in the affect of the HCA has on suppressing the synthesis of fatty acids, as well as slight lipogenesis and suppression of appetite, leading to weight loss.
However, it should be noted that consistent findings in clinical studies are lacking.
Hydroxycitric acid from Garcinia extract products or pure HCA supplements may cause side effects in some.
Numerous factors must be taken into consideration in regard to potential side effects.
Some factors include age, health status, the presence of any illness or disease condition, and weight, as well as the reason for which you are taking hydroxycitric acid and weight loss supplements.
It is recommended that before you take hydroxycitric acid or open yourself to potential hydroxycitric acid side effects, that you access user reviews on numerous websites including drugs.com, Amazon, eBay, and supplement suppliers so that you can read unbiased opinions regarding side effects, effectiveness, and dosage.
Talk to your doctor about the side effects of HCA, especially if you have been diagnosed with any medical conditions.
Hydroxycitric acid should be avoided if you’re taking antidepressant drugs, as moderate interactions may occur, and this also includes antidepressant drugs that include selective serotonin reuptake inhibitors or SSRIs, including Elavil, Prozac, Zoloft, Paxil, among others.
The potential for a medical condition known as serotonin syndrome is possible when combined with drugs like Lexapro and Demerol.
Serotonin syndrome is a serious side effect caused by interaction with antidepressants, especially if a person is taking two or more drugs that influence production of serotonin (including supplements).
Serotonin is the “feel-good” hormone produced by the brain. Antidepressants are commonly prescribed for individuals with low levels of serotonin, believed to affect depression.
Too much serotonin contributes to excessive and dangerous nerve cell activity that can be life-threatening.
While definitive studies regarding appropriate dosage recommendations for hydroxycitric acid are lacking due to insufficient data, it is believed that dosages up to 2,800 mg of HCA on a daily basis is safe for humans.
Hydroxycitric acid side effects however, may depend on dosage, strength, and purity of the HCA product. For example, some products contain 100% HCA, while others do not.
One brand of Garcinia cambogia delivers approximately 80 mg of HCA or Garcinia cambogia per capsule.
Another brand provides a powder extract and 500 mg strength, standardized for 50%, or 250 mg of HCA. The dosage and number of capsules per day will depend on such considerations.
Talk to your doctor about Hydroxycitric acid benefits, and the potential effect on your body, especially if you are being monitored for any other contributing factors, including depression.
When comparing products, pay attention to milligram strength, the percentage of HCA in the product, and recommendations for use in order to avoid hydroxycitric acid side effects.