- How Much Weight Do You Want To Lose?Enter your target weight loss (in pounds) for personalized recommendations.Goal
Top Fat Burners
Phentermine is a popular weight loss drug.
A number of drugs and compounds, mainly amphetamine in nature, were once a popular medical treatment for obesity.
However, over time, it became apparent that these drugs were dangerous to health.
Today, a number of over-the-counter as well as prescription drugs are designed to aid in weight loss, not only for those wishing to drop those last ten stubborn pounds, but for the moderately and severely overweight and obese.
Phentermine is one of those drugs used today, but in the past, a number of other drugs were popular. Click here to buy Phentermine online.
Phen 375 (Phentermine)★★★★★ 24 Reviews
Phen 375 is the top-selling diet and weight loss product online with 209,431+ customers. Phen contains pharmacy-grade ingredients to control your appetite & stimulate your metabolism... READ MORE
Read User Results
Table of Contents
A number of weight loss drugs used in the past and today are designed to work in one of four ways:
Prior to 2005, a number of over-the-counter as well as prescription drugs were recommended to severely overweight and obese individuals. However, the bulk of them are not used anymore because of their associated health dangers.
A number of over-the-counter or nonprescription drugs used in the past and today include a component known as phenylpropylamine (also commonly known as Dexatrim), which, because of its molecular makeup and its behavior as a stimulant, is likened to an amphetamine.
Dexatrim was eventually linked to increased blood pressure as well as promoting damage to blood vessels inside the brain.
It was also believed to cause a number of central nervous system disorders including hallucinations, confusion, psychotic behaviors, and strokes.
Two additional and common weight-loss drugs, fenfluramine and phentermine, were also commonly used and often used together. This combination used to be called Fen-Phen.
However, it was eventually determined that this combination of weight-loss drugs contributed to valvular regurgitation or heart valve malfunction that could prove fatal.
The medical community as well as the Food and Drug Administration was alarmed enough to quickly and efficiently remove this combination of drugs from the marketplace.
In the more recent past, the FDA approved two additional obesity medications; one known as orlistat and the other as sibutramine. These two drugs were only approved for treatment of “clinically significant” obesity.
Sibutramine, more commonly known by its brand name Meridia, is designed to work by increasing the heart rate, thereby also increasing expenditure of energy or metabolism.
Orlistat, most commonly known by the brand name Xenical, is designed to prevent the absorption of dietary fat.
While each of those two medications did show promise in regard to weight loss, discontinuation of these medications also indicated a return of the lost weight. A number of unpleasant side effects are also linked to these two drugs.
One of the most unpleasant side effects of orlistat for many was that if you went over the allowed percentage of fat intake for the day, you were at risk for quite severe, sudden, and unpleasant bouts of diarrhea.
Phentermine for is classified as a controlled substance; a Schedule IV drug. That means to buy phentermine online or in store you need a prescription.
Why? Because of its molecular makeup, similar to that of uppers or amphetamines, along with a perceived risk in the possibility of addiction, abuse, or misuse, and even overdose.
A number of studies has recently disputed these claims , but the medical community in general continues to monitor the drug as a controlled substance.
Phen is considered one of the most effective obesity weight loss drugs, used under the careful oversight of physicians and/or bariatric specialists, without the same concerns regarding heart damage as earlier weight-loss drugs.
Phentermine is also known by numerous brand names that include:
The drug belongs to the drug class of anorexiants described as central nervous system stimulants. A number of other weight-loss drugs that contain phen include those that have a combination of phentermine and topiramate (brand name Qsymia).
The actual function of topiramate in regard to weight loss has yet to be determined but it is believed to have an effect on the endocrine system.
PhenQ (Phentermine)★★★★★ 6 Reviews
PhenQ is a powerful new slimming formula combining multiple weight loss benefits to help you get the slim, sexy body you’ve always wanted... READ MORE
Read User Results
Dosage recommendations depend on an individualized approach to weight loss, obesity and weight loss management.
Because it acts as an appetite suppressant and affects the central nervous system, it is considered a beneficial medication that should always be used in conjunction with exercise and a low-calorie and nutritious diet in the treatment of obesity.
It’s most commonly recommended for the severely overweight or obese who are also prone to weight related risk factors that include diabetes, high cholesterol, and high blood pressure.
Because phentermine may be habit forming, it is recommended to only be used as a short-term weight loss drug, and under the guidance and oversight of a bariatric specialist who will moderate individuals taking the drug for effectiveness and side effects.
As mentioned, the dosage varies on a case-by-case basis as well as the brand of phentermine prescribed. For example, phentermine hydrochloride, also known by the brand names Adipex, Adipex-P and Suprenza, is often indicated for short-term use for weight loss in exogenous obesity.
This defines a situation where a severely overweight or obese individual is also diagnosed with a high potential or risk for developing a comorbidity factor or weight-related issue such as the above-mentioned high blood pressure, high cholesterol, and diabetes.
Adipex-P and Suprenza are available in a number of forms:
One of the newest kinds on the market is known as phentermine hydrochloride-topiramate, or Qsymia. Dosage recommendations for this include capsule dosages that also vary:
An even newer obesity weight loss drug is available today, recently approved by the Food and Drug Administration. Its generic name is lorcaserin but is known as the brand name Belviq.
According to drugs.com, a serious interaction between Belviq and phentermine , is believed to cause the same negative interactions as the original fenfluramine/phentermine drug combination known as Fen-Phen.
The drug combination is believed to pose an increased risk of the development of pulmonary hypertension which can cause fatalities, especially when used longer than 12 weeks.
Phentermine hydrochloride (Adipex-P and Suprenza) belongs to the therapeutic class of anorexiants or stimulants.
It is not known exactly how the weight loss drug functions in the body in regard to weight loss, other than its noted ability to suppress the appetite. It is believed to enhance the transmission of nerve impulses in the brain.
It does this by releasing stores of norepinephrine from terminals of nerves found in the brain, and more specifically, the cerebral cortex as well as the reticular activating system.
The reticular activating system also known as RAS, is the portion of the brain responsible for a number of behavioral processes including motivation, but also has an influence on circadian rhythm or sleep and waking, and other autonomic processes such as breathing and heart contractions.
Additional functions of the reticular activating system include eating, sexual libido, and elimination. It’s also believed to have an important role in the ability to focus, or in simpler terms, prevent “sensory overload”.
Phentermine hydrochloride topiramate (Qsymia) mechanisms of actions are also not completely understood.
However, research has determined that it may enhance the mediation or release of catecholamine in the hypothalamus, which results in appetite suppression, which in turn leads to a decrease in food consumption.
The actual function and mechanism of action of topiramate is unknown in relation to weight management, but is believed to enhance appetite suppression and feelings of satiety through a number of the effects on enzymes and neurotransmission signals.
Because of its similarity to amphetamines, phentermine can cause a number of side effects.
The severity of side effects depends on the individual, their overall health and wellness, and the dosage of the medication. Some of the milder side effects associated with the drug include but are not limited to:
A number of more serious side effects are associated with phentermine and include but are not limited to various body systems.
For example the central nervous system may experience symptoms like:
The cardiovascular system may experience symptoms including:
Another serious side effect of the cardiovascular system includes primary pulmonary hypertension.
This type of blood pressure defines a condition where the blood pressure in the pulmonary vein, the pulmonary artery, the capillaries, or all of them put together can cause swelling in the legs, shortness of breath, dizziness, and fainting.
According to the American Lung Association the condition is rare and generally contributes to a narrowing or construction of the blood vessels that serve the lungs.
The condition grows worse over time and can lead to high blood pressure in the lung blood vessels. It is only one of several types of pulmonary hypertension.
Phentermine may also cause symptoms in the gastrointestinal tract that contribute to:
The simple answer is that yes, phentermine can be addictive. Because of its similarity to amphetamines, doctors and bariatric specialists have long been concerned regarding misuse or abuse of the medication as well as its potential to cause addiction.
The reason for this is because over time, the drug, like many others, may lose its effectiveness, encouraging a person to take more than recommended.
When prescribing phentermine, doctors will closely monitor you for signs of dependence and/or tolerance of the medication.
According to an article in the International Journal of Obesity (“Addiction potential of phentermine prescribed during long-term treatment of obesity.”), approximately 270 formerly obese, overweight and obese individuals of various ages were treated with phentermine long-term (defined as 1.5 to 21.1 years), as well as short-term (meaning 4 to 22 days) with the doses ranging 15 to 93.75 (ATP) milligrams daily, or 18.75 to 112.5 (LTP) milligrams daily.
According to the questionnaires filled out by these subjects, the conclusions of the study showed results that psychological dependence did not tend to occur in those using phentermine for obesity, nor did it induce cravings for the drug, which are major indication of addiction.
It should be noted that this study was performed on patients who had undergone long-term treatment of phentermine in clinical intervention trials.
While phentermine may be safer than previously believed, long-term studies regarding effects on not only obesity, but on the cardiovascular system continue under study.
It should also be noted that while one of the newer phentermine anti-obesity drugs which contains a low dose of phentermine with the extended release topiramate component (known as Qsiva (Vivus) is available in the United States, it has been rejected by the European Medicines Agency.
In fact, the European Medicines Agency stated that “phentermine is known to increase heart rate and its long-term effects are not clear.
It also had concerns about the long-term psychiatric and cognitive effects of topiramate.”
As concerns regarding withdrawal symptoms, abuse, misuse, and even overdose link the similarity between phentermine and amphetamines, doctors continue to encourage caution in regard to its use and availability.
Until physicians can agree on the safety of the drug, patients are recommended to use caution in regard to adhering to dosages and recommendations provided by specialists.
When taking phentermine as directed and in appropriate dosage recommended by your doctor, you may deal with minor side effects that disappear over time and avoid more serious signs and symptoms of the drug.
While the disagreements between the potential for addiction in regard to numerous forms of phentermine are debated, users of any form of phentermine or phentermine with combinations of other drugs, should be aware of the signs and symptoms of phentermine overdose.
Signs and symptoms of phentermine hydrochloride (Adipex-P, Suprenza) overdose include:
Signs and symptoms of overdose of phentermine hydrochloride topiramate (Qsymia) include those listed above in addition to:
In addition, a number of nursing or oversight considerations must be factored into management and use of phentermine.
In addition to the ability of the drug to lose its effectiveness over time, it’s important for users to be instructed on proper administration of any form of phentermine.
It’s also important for nurses or medical staff to regularly assess bicarbonate, glucose, and electrolyte levels prior to and periodically throughout treatment.
If you wish to get off phentermine, discuss that with your doctor or bariatric specialists, as it is generally recommended that the dosage be gradually decreased when discontinuing rather than stopping “cold turkey” in order to reduce the risk of seizures.
In the event a patient needs to cease the drug immediately, he or she should be under the close supervision of a physician.
When discussing use of any form of phentermine and what it is used for with your doctor, also take into consideration that the drug may interact with other over-the-counter and prescription medications including nutritional supplements, vitamins, other weight-loss products, or those used to treat diabetes, heart conditions, including blood pressure, or glaucoma.
When used correctly, phentermine is a beneficial weight loss drug that has helped numerous individuals see success and lose weight safely while at the same time promoting changes and adaptations in lifestyle, dietary and eating habits, behaviors, and exercise levels.